Download Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina PDF

By Robert L. LaFemina

Captures the nation of the technological know-how with twenty experiences that research the newest in today’s antiviral drug discovery efforts.

  • Presents the elemental ideas of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes medical points of viral an infection with reference to remedy and toxicity.
  • Examines identified and capability ambitions in any respect phases of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a vast variety of viruses, together with HIV-1, HSV, and HCV.

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43. Dunkle, L. , A. M. Arvin, R. J. Whitley, H. A. Rotbart, H. M. , S. Feldman, A. A. Gershon, M. L. Levy, G. F. Hayden, and P. V. McGuirt. 1991. A controlled trial of acyclovir for chickenpox in normal children. N. Engl. J. Med. 325:1539–1544. 44. Earnshaw, D. , T. H. Bacon, S. J. Darlison, K. Edmonds, R. M. Perkins, and R. A. Vere Hodge. 1992. Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus. Antimicrob.

Earnshaw, D. , T. H. Bacon, S. J. Darlison, K. Edmonds, R. M. Perkins, and R. A. Vere Hodge. 1992. Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus. Antimicrob. Agents Chemother. 36:2747–2757. 45. , S. Kemp, G. Darby, and A. C. Minson. 1989. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis. J. Gen. Virol. 70:869–879. 46. Elion, G. , P. A. Furman, J. A. Fyfe, P. de Miranda, L. Beauchamp, and H.

Lietman. 1994. Activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine against human cytomegalovirus when administered as single-bolus dose and continuous infusion in in vitro cell culture perfusion system. Antimicrob. Agents Chemother. 38:2404–2408. 117. Nilsen, A. , T. Aasen, A. M. Halsos, B. R. Kinge, E. A. Tjotta, K. Wikstrom, and A. P. Fiddian. 1982. Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes. Lancet ii:571–573. 118. , and D. Faulds. 1998. Ganciclovir: an update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients.

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