Download Antiviral Drug Discovery for Emerging Diseases and by Paul F. Torrence PDF

By Paul F. Torrence

Antiviral Drug Discovery provides readers a state-of-the-art view of ways chemical innovations are being mobilized to improve novel techniques that might successfully confront rising illnesses and biowarfare. one of many subject matters mentioned are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. every one bankruptcy discusses hypothetical techniques for the invention of suitable antiviral brokers, contemporary findings on the topic of biochemistry or drug discovery, and advances within the additional improvement of verified leads within the quarter. well timed and informative, this booklet essentially delineates the efforts being made to advance new and potent broad-spectrum antiviral brokers.

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Davis, K. Viral encephalitides. In Textbook of Military Medicine, Office of the Surgeon General, Department of the Army, Washington, DC, 1997, pp. 561–589. 13. ; Handelman, S. Biohazard. Random House, New York, 1999. 14. ; Buller, R. M. L. Looking back at smallpox. Clin. Infect. Dis. 2004, 38, 882–890. 15. Basler, C. ; Klenk, H. ; Palese, P. The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc. Natl. Acad. Sci. USA 2000, 97, 12289–12294. 16. Basler, C. ; Klenk, H. ; Garcia-Sastre, A.

The only viruses in this category are a number of positive-sense RNA viruses known as encephalitis agents, since they cause febrile illness accompanied in a variable percentage of cases by infection of the central nervous system. 11,12 Their introduction by the respiratory route is expected to cause incapacitating, but generally nonfatal, illness in a high percentage of those exposed. However, aerosol transmission may also result in an increased incidence of neurological complications, since viral infection of the nasal epithelium and olfactory nerve offers a passageway into the central nervous system.

Dis. 2002, 8, 225–229. 8. ; Bartlett, J. ; Ascher, M. ; Jahrling, P. ; Osterholm, M. ; Russell, P. ; Tonat, K. Smallpox as a biological weapon: medical and public health management. JAMA 1999, 281, 2127–2137. 9. Jahrling, P. B. Viral hemorrhagic fevers. In Textbook of Military Medicine, Office of the Surgeon General, Department of the Army, Washington, DC, 1997, pp. 591–602. 10. ; Peters, C. ; Schmaljohn, A. ; Hughes, J. ; Jahrling, P. ; Johnson, K. ; Ascher, M. ; Breman, J. ; Eitzen, E. M. ; Henderson, D.

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