By Adriel R. Bonilla
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Extra info for Antibiotic resistance : causes and risk factors, mechanisms and alternatives
It is well-known that bacterial translocation results in various negative clinical infections to the host. However, antibiotic-resistant probiotic translocation is even more detrimental to the health of the patient than the translocation of endogenous bacteria. The transfer of live antibiotic-resistant probiotics from the gastrointestinal tract to other organ via the circulation may potentially cause systemic infections such as bacteremia, septicemia and multiple organ failure (Liong, 2008). Metabolites produced by either live or non-viable translocated antibiotic-resistant probiotics have also been reported to produce negative side effects in the host.
Any adverse effects in these clinical trials will be monitored and published in order to demonstrate the efficacy of a particular probiotic strain (FAO/WHO, 2002) 16 Min-Tze Liong, Siok-Koon Yeo, Chiu-Yin Kuan et al. , 2008). All clinical isolates should be deposited in international culture collections center under conditions of restricted distribution. , 2008). , 2003) of probiotic strains. The existing documentation are merely recommendations and reports regarding the safety issue of probiotics in foods that have been published by various regulatory bodies from different countries.
In fact, bacteriocin-producing probiotics could also be used to prevent the growth of antibiotic-resistant strains. The production of these antimicrobial factors in the gut would have an antagonistic effect on the resistant strains, which would confer a competitive advantage to the bacteriocin-producing bacteria in the microenvironment. , 2008). Therefore, it is expected that bacteriocin-producing probiotics could reduce the colonization by antibiotic-resistant strains. Past studies have demonstrated that strains of L.